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Generation of hydrogen peroxide in the developing rat heart: the role of elastin metabolism
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SYSNO ASEP 0369506 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Generation of hydrogen peroxide in the developing rat heart: the role of elastin metabolism Author(s) Wilhelm, J. (CZ)
Ošťádalová, Ivana (FGU-C) RID
Vytášek, R. (CZ)
Vajner, L. (CZ)Source Title Molecular and Cellular Biochemistry. - : Springer - ISSN 0300-8177
Roč. 358, 1-2 (2011), s. 215-220Number of pages 6 s. Language eng - English Country US - United States Keywords rat heart ; ontogenetic development ; hydrogen peroxide ; elastin ; fluorescence Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000296286700024 DOI 10.1007/s11010-011-0937-8 Annotation The production of hydrogen peroxide (H2O2) during development (starting from day 21 after conception up to adulthood) of the rat heart was studied. H2O2, that modifies elastin, is produced by lysyl oxidase since day 4 up to day 15 only extracellularly, later on even intracellular production was observed. The specific inhibitor of lysyl oxadase abolished production of H2O2 Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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