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Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells
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SYSNO ASEP 0369496 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells Author(s) Neužil, Jiří (BTO-N) RID
Černý, Jiří (BTO-N) RID, ORCID
Dyason, J.C. (AU)
Dong, L.-F. (AU)
Ralph, S.J. (AU)Source Title Molecular Nutrition & Food Research. - : Wiley - ISSN 1613-4125
Roč. 55, č. 10 (2011), s. 1543-1551Number of pages 8 Language eng - English Country US - United States Keywords Vitamin E analogues ; mitochondrial complex II ; modelling Subject RIV CE - Biochemistry CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000296547700012 DOI 10.1002/mnfr.201100066 Annotation Vitamin E (VE) analogues, epitomised by the prototypic alpha-tocopheryl succinate (alpha-TOS), are potent anti-cancer agents. alpha-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Q(P)) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R(2) value >0.8) with their toxicity to cancer cells. These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
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