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The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?
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SYSNO ASEP 0369486 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? Author(s) Zobalová, Renata (BTO-N) RID
Prokopová, Kateřina (BTO-N) ORCID
Stantic, M. (US)
Stapelberg, M. (US)
Dong, L.-F. (US)
Ralph, S.J. (US)
Akporiaye, E. (US)
Neužil, Jiří (BTO-N) RIDSource Title Antioxidants & Redox Signaling. - : Mary Ann Liebert - ISSN 1523-0864
Roč. 15, č. 12 (2011), s. 2989-3002Number of pages 13 Language eng - English Country US - United States Keywords Cancer stem-like cells ; protein CD133 ; apoptosis Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/08/0811 GA ČR - Czech Science Foundation (CSF) GA305/07/1008 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000296588900006 DOI 10.1089/ars.2010.3785 Annotation Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
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