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Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii
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SYSNO ASEP 0369375 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii Author(s) Cahlíková, L. (CZ)
Zavadil, S. (CZ)
Macáková, K. (CZ)
Valterová, Irena (UOCHB-X) RID, ORCID
Kulhánková, A. (CZ)
Hošťálková, A. (CZ)
Kuneš, J. (CZ)
Opletal, L. (CZ)Number of authors 8 Source Title Natural Product Communications - ISSN 1934-578X
Roč. 6, č. 12 (2011), s. 1827-1830Number of pages 4 s. Language eng - English Country US - United States Keywords Nerine bowdenii ; GC/MS ; belladine ; acetylcholinesterase Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000298445300010 Annotation Amaryllidaceae species are known as ornamental plants. Some contain galanthamine, an acetylcholinesterase inhibitor. The chemical composition of the alkaloid extract of bulbs of Nerine bowdenii Watson has been analyzed by means of GC/MS. Twenty-two compounds were detected and nineteen of them identified, one of which was belladine. The alkaloid extract showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50= 87.9.+-.3.5 .mu.g/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 = 14.8.+-.1.1 .mu.g/mL). Belladine inhibited HuAChE and HuBuChE in a dose-dependent manner with IC50 values of 781.+-.12.5 .mu.M and 284.8±4.2 .mu.M, respectively. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2012
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