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Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates

SYSNO ASEP	0369214
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates
Author(s)	Jansa, Petr (UOCHB-X)_RID Kolman, Viktor (UOCHB-X)_RID Kostinová, Alexandra (UOCHB-X) Dračínský, Martin (UOCHB-X)_{RID, ORCID} Mertlíková-Kaiserová, Helena (UOCHB-X)_{RID, ORCID} Janeba, Zlatko (UOCHB-X)_{RID, ORCID}
Number of authors	6
Source Title	Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765 Roč. 76, č. 10 (2011), s. 1187-1198
Number of pages	12 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	nucleosides ; nucleotides ; phosphorus ; fluorine ; biological activity ; antibiotics
Subject RIV	CC - Organic Chemistry
R&D Projects	VG20102015046 GA MV - Ministry of Interior (MV)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000298004400003
DOI	10.1135/cccc2011105
Annotation	Efficient synthesis of acyclic nucleosides and acyclic nucleoside phosphonates substituted at the C-2′ position of the aliphatic part by the trifluoromethyl group is described, starting from trifluoromethyloxirane. None of the prepared compounds exhibit any antiviral, antiproliferative or anti-toxin activities.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1