Number of the records: 1

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

SYSNO ASEP	0368977
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
Author(s)	Keunen, O. (LU) Johansson, M. (SE) Oudin, A. (LU) Sanzey, M. (LU) Rahim, S. A. (LU) Fack, F. (LU) Thorsen, F. (NO) Taxt, T. (NO) Bartoš, M. (CZ) Jiřík, Radovan (UPT-D)_{RID, ORCID, SAI} Miletic, H. (NO) Wang, J. (NO) Stieber, D. (LU) Stuhr, L. (NO) Moen, I. (NO) Rygh, C. B. (NO) Bjerkvig, R. (NO) Niclou, S. (LU)
Number of authors	18
Source Title	Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424 Roč. 108, č. 9 (2011), s. 3749-3754
Number of pages	6 s.
Language	eng - English
Country	US - United States
Keywords	angiogenesis ; glioma ; metabolism ; perfusion
Subject RIV	FS - Medical Facilities ; Equipment
CEZ	AV0Z20650511 - UPT-D (2005-2011)
UT WOS	000287844400057
EID SCOPUS	79952740612
DOI	10.1073/pnas.1014480108
Annotation	Bevacizumab, an antibody against vascular endothelial growth factor (VEGF), is a promising, yet controversial, drug in human glioblastoma treatment (GBM). Its effects on tumor burden, recurrence, and vascular physiology are unclear. We therefore determined the tumor response to bevacizumab at the phenotypic, physiological, and molecular level in a clinically relevant intracranial GBM xenograft model derived from patient tumor spheroids. Using anatomical and physiological magnetic resonance imaging (MRI), we show that bevacizumab causes a strong decrease in contrast enhancement while having only a marginal effect on tumor growth. Interestingly, dynamic contrast-enhanced MRI revealed a significant reduction of the vascular supply, as evidenced by a decrease in intratumoral blood flow and volume and, at the morphological level, by a strong reduction of large- and medium-sized blood vessels. Electron microscopy revealed fewer mitochondria in the treated tumor cells.
Workplace	Institute of Scientific Instruments
Contact	Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178
Year of Publishing	2012

Number of the records: 1