Number of the records: 1

(Carboxydiamine)Pt(II) complexes of a combretastatin A-4 analogous chalcone: the influence of the diamine ligand on DNA binding and anticancer effects

SYSNO ASEP	0368769
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	(Carboxydiamine)Pt(II) complexes of a combretastatin A-4 analogous chalcone: the influence of the diamine ligand on DNA binding and anticancer effects
Author(s)	Zoldakova, M. (DE) Biersack, B. (DE) Kostrhunová, Hana (BFU-R)_{RID, ORCID} Ahmad, A. (US) Padhye, S. (US) Sarkar, F.H. (US) Schobert, R. (DE) Brabec, Viktor (BFU-R)_{RID, ORCID}
Number of authors	8
Source Title	MedChemComm. - : Royal Society of Chemistry - ISSN 2040-2503 Roč. 2, č. 6 (2011), s. 493-499
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	platinum ; DNA binding ; anticancer effects
Subject RIV	BO - Biophysics
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000292953500006
DOI	10.1039/clmd00042j
Annotation	The combretastatin A-4 analogue m-hydroxychalcone was esterified with a (1-carboxyethane-2,3-diamine)dichloridoplatinum(II) fragment to give complex which was more active against various cancer cell lines (IC50<1 mM) than its analogue bearing a 6-aminomethylnicotinate ligand.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2012

Number of the records: 1