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An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family
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SYSNO ASEP 0368706 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family Author(s) Gäde, G. (ZA)
Šimek, Petr (BC-A) RID, ORCID
Marco, H. G. (ZA)Number of authors 3 Source Title Biochemical and Biophysical Research Communications. - : Elsevier - ISSN 0006-291X
Roč. 414, č. 3 (2011), s. 592-597Number of pages 6 s. Language eng - English Country US - United States Keywords Insects ; stink bug ; Nezara viridula Subject RIV ED - Physiology R&D Projects GAP206/10/2401 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000298519500026 DOI 10.1016/j.bbrc.2011.09.127 Annotation An octapeptide of the adipokinetic hormone (AKH) peptide family is identified in corpora cardiaca of the stink bug, Nezara viridula. This is the second AKH in N. viridula and it has a hydroxyproline residue at position 6, whereas the major AKH (known as Panbo-RPCH) has Pro as the sixth amino acid residue. Various extraction procedures were followed to ascertain whether the hydroxylation is an artefact of extraction, or whether it is due to a true post-translational modification at the prohormone level. The proline hydroxylation is unique for invertebrate neuropeptides, while it has been described in the vertebrate gonadotropin-releasing hormone (GnRH). The current finding is another piece of evidence that AKH and GnRH form a peptide superfamily and are closely related evolutionarily. Biologically, [Hyp6]-Panbo-RPCH is active in vivo as an AKH, causing hyperlipaemia in the stink bug at low doses, indicating that it is an endogenous, mature and functional hormone in this insect species. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
Number of the records: 1