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Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord
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SYSNO ASEP 0368699 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord Author(s) Perrin, F. E. (ES)
Gerber, Y. N. (ES)
Teigell, M. (FR)
Lonjon, N. (FR)
Boniface, G. (FR)
Bauchet, L. (FR)
Rodríguez Arellano, Jose Julio (UEM-P)
Hugnot, J. P. (FR)
Privat, A. M. (ES)Source Title Cell Death & Disease. - : Springer - ISSN 2041-4889
Roč. 2, - (2011), e218Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords genito-urinary tract ; locomotion ; nociceptive pathway Subject RIV FH - Neurology R&D Projects GA309/09/1696 GA ČR - Czech Science Foundation (CSF) GAP304/11/0184 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000296587500007 DOI 10.1038/cddis.2011.98 Annotation Here, we have performed a preliminary mapping of serotonergic processes and serotonin-lA (5-HT(1A)) receptors in thoracic and lumbar segments of the human spinal cord. 5-HT profiles in human spinal cord are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at lumbar level. 5-HT(1A) receptors are present in the same area, but are more densely expressed at lumbar level. These findings pave the way for local specific therapies involving cellular and/or pharmacological tools targeting the serotonergic system. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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