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N9-Substituted N(6)-[(3-methylbut-2-en-1-yl)amino]purine derivatives and their biological activity in selected cytokinin bioassays

SYSNO ASEP	0368655
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	N9-Substituted N(6)-[(3-methylbut-2-en-1-yl)amino]purine derivatives and their biological activity in selected cytokinin bioassays
Author(s)	Mik, V. (CZ) Szüčová, Lucie (UEB-Q)_{RID, ORCID} Spíchal, Lukáš (UEB-Q)_{RID, ORCID} Plíhal, O. (CZ) Nisler, Jaroslav (UEB-Q)_{RID, ORCID} Zahajská, L. (CZ) Doležal, Karel (UEB-Q)_{RID, ORCID} Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Number of authors	8
Source Title	Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896 Roč. 19, č. 23 (2011), s. 7244-7251
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	N6-[(3-Methylbut-2-en-1-yl)amino]purine ; Isopentenyladenine derivatives ; N9-Substituted derivatives ; Cytokinins ; Cytokinin receptors
Subject RIV	EF - Botanics
R&D Projects	ED0007/01/01 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA522/09/1576 GA ČR - Czech Science Foundation (CSF)
UT WOS	000296752300031
DOI	10.1016/j.bmc.2011.09.052
Annotation	Rational design is one of the latest ways how to evaluate particular activity of signal molecules, for example cytokinin derivatives. A series of N(6)-[(3-methylbut-2-en-1-yl)amino]purine (iP) derivatives specifically substituted at the N9 atom of purine moiety by tetrahydropyran-2-yl, ethoxyethyl, and C2-C4 alkyl chains terminated by various functional groups were prepared. The reason for this rational design was to reveal the relationship between specific substitution at the N9 atom of purine moiety of iP and cytokinin activity of the prepared compounds. The synthesis was carried out either via 6-chloro-9-substituted intermediates prepared originally from 6-chloropurine, or by a direct alkylation of N9 atom of N(6)-[(3-methylbut-2-en-1-yl)amino]purine.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2012

Number of the records: 1