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Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression
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SYSNO ASEP 0368653 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression Author(s) Gábelová, A. (SK)
Valovičová, Z. (SK)
Mesárošová, M. (SK)
Trilecová, L. (CZ)
Hrubá, E. (CZ)
Marvanová, S. (CZ)
Krčmář, P. (CZ)
Milcová, Alena (UEM-P)
Schmuczerová, Jana (UEM-P) RID
Vondráček, J. (CZ)
Machala, M. (CZ)
Topinka, Jan (UEM-P) RID, ORCIDSource Title Environmental and Molecular Mutagenesis. - : Wiley - ISSN 0893-6692
Roč. 52, č. 8 (2011), s. 636-645Number of pages 10 s. Language eng - English Country US - United States Keywords dibenzo[c,g]carbazoles ; DNA strand breaks ; DNA adducts Subject RIV DN - Health Impact of the Environment Quality R&D Projects 2B08005 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50040702 - BFU-R (2007-2013) AV0Z50040507 - BFU-R (2005-2011) UT WOS 000296861100005 EID SCOPUS 80053643527 DOI 10.1002/em.20664 Annotation The goal of this study was to investigate the genotoxicity of dibenzocarbazoles in human hepatoma HepG2 cells and to infer potential mechanisms underlying the biological activity of particular carcinogen. All dibenzocarbazoles, regardless the tissue specificity, induced significant DNA strand break levels and micronuclei in HepG2 cells; though a mitotic spindle dysfunction rather than a chromosome breakage was implicated in N-MeDBC-mediated micronucleus formation. Our data clearly demonstrated differences in the mechanisms involved in the biological activity of DiMeDBC and N-MeDBC in human hepatoma cells; the genotoxicity of these DBC derivatives is closely related to CYP1A1/2 expression. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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