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Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes
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SYSNO ASEP 0368636 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes Author(s) Řehoř, I. (CZ)
Vilímová, V. (CZ)
Jendelová, Pavla (UEM-P) RID, ORCID
Kubíček, V. (CZ)
Jirák, D. (CZ)
Herynek, V. (CZ)
Kapcalová, Miroslava (UEM-P)
Kotek, J. (CZ)
Černý, J. (CZ)
Hermann, P. (CZ)
Lukeš, I. (CZ)Source Title Journal of Medicinal Chemistry. - : American Chemical Society - ISSN 0022-2623
Roč. 54, č. 14 (2011), s. 5185-5194Number of pages 10 s. Language eng - English Country US - United States Keywords MRI contrast agent ; stem-cell therapy ; Ti02 particles Subject RIV CA - Inorganic Chemistry CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000292892300021 DOI 10.1021/jm200449y Annotation Multimodal imaging-therapeutic nanoprobe TiO2@RhdGd was prepared and successfully used for in vitro and in vivo cell tracking as well as for killing of cancer cells in vitro. TiO2 nanoparticles were used as a core for phosphonic acid modified functionalities, responsible for contrast in MRI and optical imaging. The probe shows high 1H relaxivity and relaxivity density values. Presence of fluorescent dye allows for visualization by means of fluorescence microscopy. The applicability of the probe was studied, using mesenchymal stem cells, cancer HeLa cells, and T-lymphocytes. The probe did not exhibit toxicity in any of these systems. Labeled cells were successfully visualized in vitro by means of fluorescence microscopy and MRI. Furthermore, it was shown that the probe TiO2@RhdGd can be changed into a cancer cell killer upon UV light irradiation. The above stated results represent a valuable proof of a principle showing applicability of the probe design for diagnosis and therapy. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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