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In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism

SYSNO ASEP	0368606
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism
Author(s)	Siller, M. (CZ) Anzenbacher, P. (CZ) Anzenbacherová, E. (CZ) Doležal, Karel (UEB-Q)_{RID, ORCID} Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Number of authors	5
Source Title	Xenobiotica. - : Taylor & Francis - ISSN 0049-8254 Roč. 41, č. 11 (2011), s. 934-944
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	DRUG-DRUG INTERACTIONS ; SUBSTRATE-SPECIFICITY ; R-ROSCOVITINE ; GLUCURONIDATION ; CELLS
Subject RIV	EF - Botanics
R&D Projects	GA301/08/1649 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000295618400002
DOI	10.3109/00498254.2011.593209
Annotation	1. Neutrophil growth factors (NGFs) stimulate neutrophil growth and survival. The first synthetic cytokinin-derived NGF was recently discovered and is a prospective drug owing to its potential use in anti-inflammatory therapy. The metabolism of some cytokinin-derived drugs (e.g. R-roscovitine, olomoucine II) has already been studied and it has been shown that they may give rise to drug-drug interactions. 2. In this in vitro study, the interactions of the novel neutrophil growth factor NGF1568 with two of the main classes of human drug-metabolizing enzymes, cytochromes P450 (CYPs) and UDP-glucuronosyltransferases (UGTs), were tested. Of the CYPs evaluated, NGF1568 was found to inhibit only CYP2C9, by an uncompetitive mechanism and with a K(i) value of 349 mu M.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2012

Number of the records: 1