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THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE
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SYSNO ASEP 0368591 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE Author(s) Jedinák, L. (CZ)
Kryštof, Vladimír (UEB-Q) RID, ORCID
Cankař, Petr (UEB-Q) ORCIDNumber of authors 3 Source Title Heterocycles. - : Elsevier - ISSN 0385-5414
Roč. 88, č. 2 (2011), s. 371-383Number of pages 13 s. Language eng - English Country JP - Japan Keywords Knoevenagel Condensation ; Olefin Reduction ; CDK ; Hydrazine Cycloaddition ; Pyrazole-3,5-diamine Subject RIV CE - Biochemistry R&D Projects GA301/08/1649 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000287562900012 DOI 10.3987/COM-10-12101 Annotation The three-step synthesis of 4-benzyl-1H-pyrazole-3,5-diamines 2 from commercially available aldehydes 3 is given. The Knoevenagel condensation was utilized to assemble the initial carbon framework, resulting in the benzylidenemalononitriles 4 which were directly transformed by the reduction of the electron deficient C=C bond to benzylmalononitriles 5. Subsequent cycloaddition of hydrazine with 5 afforded the desired pyrazoles 2. Due to the high similarity with 4-arylazo-1H-pyrazole-3,5-diamines, the biological activities of the 4-benzyl-1H-pyrazole-3,5-diamines 2 were evaluated while focusing on the inhibition of cyclin-dependent kinases (CDKs), but no significant results were obtained. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2012
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