Number of the records: 1
Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair
- 1.
SYSNO ASEP 0368381 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair Author(s) Kubinová, Šárka (UEM-P) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCID
Hejčl, Aleš (UEM-P) RID, ORCID
Plichta, Zdeněk (UMCH-V)
Kotek, Jiří (UMCH-V) RID
Syková, Eva (UEM-P) RIDSource Title Journal of Biomedical Materials Research. Part A. - : Wiley - ISSN 1549-3296
Roč. 99, č. 4 (2011), s. 618-629Number of pages 12 s. Language eng - English Country US - United States Keywords 2-hydroxyethyl methacrylate ; scaffold ; spinal cord repair Subject RIV FH - Neurology R&D Projects IAA500390902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GAP304/11/0731 GA ČR - Czech Science Foundation (CSF) GPP304/11/P633 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000297019200012 DOI 10.1002/jbm.a.33221 Annotation Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
Number of the records: 1