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Expression and characterization of c-Myb in prenatal odontogenesis
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SYSNO ASEP 0368272 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expression and characterization of c-Myb in prenatal odontogenesis Author(s) Matalová, Eva (UZFG-Y) RID
Buchtová, Marcela (UZFG-Y) RID, ORCID
Tucker, A. S. (GB)
Bender, T. P. (US)
Janečková, Eva (UZFG-Y)
Lungová, V. (CZ)
Balková, Simona (UZFG-Y)
Šmarda, J. (CZ)Number of authors 8 Source Title Development Growth & Differentiation - ISSN 0012-1592
Roč. 53, č. 6 (2011), s. 793-803Number of pages 11 s. Language eng - English Country JP - Japan Keywords morphogenesis ; mouse ; Myb Subject RIV FF - HEENT, Dentistry R&D Projects KJB500450802 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GAP304/11/1418 GA ČR - Czech Science Foundation (CSF) GP304/08/P289 GA ČR - Czech Science Foundation (CSF) GC524/08/J032 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000293902200004 DOI 10.1111/j.1440-169X.2011.01287.x Annotation The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
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