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MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic
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SYSNO ASEP 0367822 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic Author(s) Pardini, Barbara (UEM-P)
Kumar, R. (DE)
Naccarati, Alessio (UEM-P)
Prasad, R. B. (DE)
Försti, A. (DE)
Poláková, Veronika (UEM-P) RID
Vodičková, Ludmila (UEM-P) RID
Novotný, J. (CZ)
Hemminki, K. (DE)
Vodička, Pavel (UEM-P) RIDSource Title Mutation Research - Genetic Toxicology and Environmental Mutagenesis. - : Elsevier - ISSN 1383-5718
Roč. 721, č. 1 (2011), s. 74-80Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords Colorectal cancer risk ; MTHFR ; MTRR Subject RIV EB - Genetics ; Molecular Biology R&D Projects GP305/09/P194 GA ČR - Czech Science Foundation (CSF) GAP304/10/1286 GA ČR - Czech Science Foundation (CSF) NS10230 GA MZd - Ministry of Health (MZ) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000288843300006 DOI 10.1016/j.mrgentox.2010.12.008 Annotation Polymorphic variants in genes involved in metabolisms of dietary folate may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR and MTRR genes with the risk for colorectal cancer in the Czech Republic. We have concluded that the 677TT genotype and the TA haplotype in the MTHFR gene may also play a role in colorectal cancer risk in the Czech population. No difference in the distribution between cases and controls was observed for the haplotypes based on the four polymorphisms in the MTRR gene. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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