Number of the records: 1
Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1
- 1.
SYSNO ASEP 0367814 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 Author(s) Winkelmann, J. (DE)
Czamara, D. (DE)
Schormair, B. (DE)
Knauf, F. (DE)
Schulte, E. C. (DE)
Vodička, Pavel (UEM-P) RIDNumber of authors 57 Source Title PLoS Genetics - ISSN 1553-7390
Roč. 7, č. 7 (2011), e1002171Number of pages 10 s. Language eng - English Country US - United States Keywords TOX3 ; transcription ; common genetic-variants Subject RIV EB - Genetics ; Molecular Biology R&D Projects NR8563 GA MZd - Ministry of Health (MZ) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000293338600020 DOI 10.1371/journal.pgen.1002171 Annotation Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age, which severely harms life comfort and working ability. We conducted a genome-wide association study (GWA) for RLS in 922 cases and 1,526 controls (using 301,406 SNPs) followed by a replication of 76 candidate SNPs in 3,935 cases and 5,754 controls, all of European ancestry. We identified several susceptibility loci, two of them novel. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
Number of the records: 1