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Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites

SYSNO ASEP	0367760
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites
Author(s)	Kořený, Luděk (BC-A)_RID Sobotka, Roman (MBU-M)_{RID, ORCID} Janouškovec, J. (CZ) Keeling, P. J. (CA) Oborník, Miroslav (BC-A)_{RID, ORCID}
Source Title	Plant Cell. - : Oxford University Press - ISSN 1040-4651 Roč. 23, č. 9 (2011), s. 3454-3462
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	YEAST SACCHAROMYCES-CEREVISIAE ; HEME-BIOSYNTHESIS PATHWAY ; PLASMODIUM-FALCIPARUM ; MALARIA PARASITE ; 5-AMINOLEVULINATE SYNTHASE ; SECONDARY PLASTIDS ; TOXOPLASMA-GONDII ; PROTEIN-TRANSPORT ; EUGLENA-GRACILIS ; METABOLIC MAPS
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA206/08/1423 GA ČR - Czech Science Foundation (CSF)
	IAA601410907 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000296739100030
DOI	10.1105/tpc.111.089102
Annotation	Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2012

Number of the records: 1