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ANTI-INFLAMMATORY EFFECTS OF CHAMOMILE ESSENTIAL OIL IN MICE
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SYSNO ASEP 0367752 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title ANTI-INFLAMMATORY EFFECTS OF CHAMOMILE ESSENTIAL OIL IN MICE Author(s) Fabian, D. (SK)
Juhás, Štefan (UZFG-Y) RID, ORCID
Bukovska, A. (SK)
Bujňáková, D. (SK)
Grešáková, L. (SK)
Koppel, J. (SK)Number of authors 6 Source Title Slovak Journal of Animal Science - ISSN 1335-3683
Roč. 44, č. 3 (2011), s. 111-116Number of pages 6 s. Language eng - English Country SK - Slovakia Keywords inflammation ; carrageenan paw oedema ; TNBS colitis Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50450515 - UZFG-Y (2005-2011) Annotation Essential oils are plant secondary metabolites with positive pharmacological properties, e.g. anti-oxidative, antimicrobial or immunomodulative, but they can have toxic and allergic effects as well. The aim of this study was to analyze anti-inflammatory effects of chamomile essential oil dietary administration in carrageenan paw oedema and trinitrobenzene sulfonic acid (TNBS) colitis. Mice received chamomile essential oil in three concentrations (5000, 2500 and 1250 ppm) in the standard rodent diet starting two weeks before induction of carrageenan paw oedema and TNBS colitis. Dietary supplementations with 5000 ppm of chamomile essential oil significantly reduced both the oedema and the weight of mice paws compared with control. The same dose of chamomile essential oil showed protective effect on colonic mucosa and improved macroscopic signs of TNBS-induced colonic inflammation. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
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