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Determination of Oxygen Radical Absorbance Capacity of Black Cumin (Nigella sativa) Seed Quinone Compounds
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SYSNO ASEP 0367700 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Determination of Oxygen Radical Absorbance Capacity of Black Cumin (Nigella sativa) Seed Quinone Compounds Author(s) Tesařová, H. (CZ)
Svobodová, B. (CZ)
Kokoška, L. (CZ)
Maršík, Petr (UEB-Q) RID, ORCID
Přibylová, Marie (UEB-Q)
Landa, Přemysl (UEB-Q) RID, ORCID
Vadlejch, J. (CZ)Source Title Natural Product Communications - ISSN 1934-578X
Roč. 6, č. 2 (2011), s. 213-216Number of pages 4 s. Language eng - English Country US - United States Keywords Antioxidative activity ; Dihydrothymoquinone ; Thymoquinone Subject RIV GM - Food Processing R&D Projects GA525/08/1179 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000287613800014 Annotation In this study, the antioxidant capacities of main quinone constituents of Nigella saliva seeds, namely dithymoquinone (1), thymohydroquinone (2) and thymoquinone (3), were compared using DPPH and ORAC methods. The best scavenging activity was produced by 2, which showed a remarkable activity of 2.60 Trolox equivalents (TE) in a concentration range between 1.6 and 6.4 mu g/mL and IC50 value of 2.4 mu g/mL, in ORAC and DPPH assays, respectively. Contrastingly, 3 possessed only weak DPPH scavenging efficacy (IC50 = 170 mu g/mL) but significant antioxidative action of 1.91 TE in ORAC assay. No effect has been observed for 1. Additionally, modified protocol for synthesis of 2 has been developed with aim to enhance its availability for further studies as well as for its future potential use. Based on the results of this study, we conclude that 2 could be considered as a compound with prospective antioxidative properties. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2012
Number of the records: 1