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Neurogenesis in Alzheimer´s disease
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SYSNO ASEP 0367673 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Neurogenesis in Alzheimer´s disease Author(s) Rodríguez Arellano, Jose Julio (UEM-P)
Verkhratsky, Alexei (UEM-P)Source Title Journal of Anatomy. - : Wiley - ISSN 0021-8782
Roč. 219, č. 1 (2011), s. 78-89Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords Alzheimer's disease ; hippocampus ; neurodegeneration Subject RIV FH - Neurology R&D Projects GA309/09/1696 GA ČR - Czech Science Foundation (CSF) GAP304/11/0184 GA ČR - Czech Science Foundation (CSF) GA309/08/1381 GA ČR - Czech Science Foundation (CSF) GA305/08/1384 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000291401100009 EID SCOPUS 79958230697 DOI 10.1111/j.1469-7580.2011.01343.x Annotation Here, we overviewed the relations between adult neurogenesis and Alzheimer’s disease, and try to analyse the controversies in the field. We also summarised recent data obtained in the triple transgenic model of AD that show time- and region-specific impairment of neurogenesis, which may account for the early changes in synaptic plasticity and cognitive impairments that develop prior to gross neurodegenerative alterations and that could underlie new rescue therapies. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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