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Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?
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SYSNO ASEP 0367669 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission? Author(s) Olabarria, M. (GB)
Noristani, H. N. (GB)
Verkhratsky, Alexei (UEM-P)
Rodríguez Arellano, Jose Julio (UEM-P)Source Title Molecular Neurodegeneration
Roč. 6, č. 1 (2011), s. 55-63Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords astroglia ; glutamine synthetase ; Alzheimer?'?s disease Subject RIV FH - Neurology R&D Projects GA309/09/1696 GA ČR - Czech Science Foundation (CSF) GAP304/11/0184 GA ČR - Czech Science Foundation (CSF) GA305/08/1384 GA ČR - Czech Science Foundation (CSF) GA309/08/1381 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000294536400001 EID SCOPUS 79960887452 DOI 10.1186/1750-1326-6-55 Annotation Here, we report a decline in astrocytic glutamine synthetase (GS) in two major cognitive areas of the hippocampus (the dentate gyrus, DG and the CA1) in 3xTg-AD animals) aged between 9 and 18 months. Such a decrease in astrocytic GS is directly associated with the presence of Aβ deposits indicating AD-related impairments of glutamate homeostatic system, at the advanced and late stages of the disease, which may affect the efficacy of glutamatergic transmission in the diseased brain that may contribute to the cognitive deficiency. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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