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Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
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SYSNO ASEP 0367668 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro Author(s) Hošek, J. (CZ)
Bartoš, M. (CZ)
Chudík, S. (CZ)
Dall’Acqua, S. (IT)
Innocenti, G. (GB)
Kartal, M. (TR)
Kokoška, L. (CZ)
Kollár, P. (CZ)
Kutil, Zsófia (UEB-Q)
Landa, Přemysl (UEB-Q) RID, ORCID
Marek, R. (CZ)
Závalová, V. (CZ)
Žemlička, M. (CZ)
Šmejkal, K. (CZ)Source Title Journal of Natural Products. - : American Chemical Society - ISSN 0163-3864
Roč. 74, č. 4 (2011), s. 614-619Number of pages 6 s. Language eng - English Country US - United States Keywords NF-KAPPA-B ; CUDRANIA-TRICUSPIDATA ; ROOT BARK Subject RIV GM - Food Processing R&D Projects LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GP525/09/P528 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000289742300011 DOI 10.1021/np100638h Annotation Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound acts as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2012
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