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Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors
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SYSNO ASEP 0367444 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors Author(s) Soukup, O. (CZ)
Krůšek, Jan (FGU-C) RID, ORCID
Kaniaková, Martina (FGU-C) RID, ORCID
Kumar, U. K. (SE)
Oz, M. (AE)
Jun, D. (CZ)
Fusek, J. (CZ)
Kuča, K. (CZ)
Tobin, G. (SE)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 60, č. 4 (2011), s. 679-686Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords organophosphates ; patch-clamp ; nicotinic receptors ; reactivator ; isometric muscle contraction ; TE671 cells Subject RIV FR - Pharmacology ; Medidal Chemistry R&D Projects GA202/09/0806 GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000295057100010 Annotation Antinicotinic properties of oximes reactivators were examined by in-vitro and in-vivo methods. We found that oximes (HI-6, obidoxime, K027 and K203) antagonize the nicotinic receptors of both adult and embryonic form with different potency Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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