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Virtual Mutagenesis of the Yeast Cyclins Genetic Network Reveals Complex Dynamics of Transcriptional Control Networks

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    SYSNO ASEP0367428
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleVirtual Mutagenesis of the Yeast Cyclins Genetic Network Reveals Complex Dynamics of Transcriptional Control Networks
    Author(s) Vohradská, E. (CZ)
    Vohradský, Jiří (MBU-M) RID, ORCID
    Source TitlePLoS ONE. - : Public Library of Science - ISSN 1932-6203
    Roč. 6, č. 4 (2011), s. 1-9
    Number of pages9 s.
    Languageeng - English
    CountryUS - United States
    KeywordsREGULATORY NETWORKS ; SACCHAROMYCES-CEREVISIAE ; CELL-CYCLE
    Subject RIVEE - Microbiology, Virology
    R&D ProjectsGA310/07/1009 GA ČR - Czech Science Foundation (CSF)
    GAP302/11/0229 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z50200510 - MBU-M (2005-2011)
    UT WOS000290016800020
    DOI10.1371/journal.pone.0018827
    AnnotationStudy of genetic networks has moved from qualitative description of interactions between regulators and regulated genes to the analysis of the interaction dynamics. This paper focuses on the analysis of dynamics of one particular network – the yeast cyclins network. Using a dedicated mathematical model of gene expression and a procedure for computation of the parameters of the model from experimental data, a complete numerical model of the dynamics of the cyclins genetic network was attained. The model allowed for performing virtual experiments on the network and observing their influence on the expression dynamics of the genes downstream in the regulatory cascade. Results show that when the network structure is more complicated, and the regulatory interactions are indirect, results of gene deletion are highly unpredictable
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2012
Number of the records: 1  

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