Number of the records: 1
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat
- 1.
SYSNO ASEP 0367313 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat Author(s) Morrissey, C. (GB)
Grieve, I. (GB)
Heinig, M. (DE)
Atanur, S. (GB)
Petretto, E. (GB)
Pravenec, Michal (FGU-C) RID, ORCID
Hubner, N. (DE)
Aitman, T. J. (GB)Source Title Physiological Genomics. - : American Physiological Society - ISSN 1094-8341
Roč. 43, č. 21 (2011), s. 1207-1218Number of pages 12 s. Language eng - English Country US - United States Keywords eQTL ; spontaneously hypertensive rat ; quantitative trait transcript ; sequence variation Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/08/0166 GA ČR - Czech Science Foundation (CSF) ME10019 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000296758000003 DOI 10.1152/physiolgenomics.00210.2010 Annotation The Spontaneously Hypertensive rat (SHR) is a widely used rodent model of hypertension and metabolic syndrome. By integration of genomic sequence, eQTL and QTT datasets we have identified several genes that are strong positional candidates for pathophysiological traits observed in the SHR strain. These findings provide a basis for the functional testing and ultimate elucidation of the molecular basis of these metabolic and cardiovascular phenotypes Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
Number of the records: 1