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Nanomechanics of magnetically driven cellular endocytosis
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SYSNO ASEP 0367265 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nanomechanics of magnetically driven cellular endocytosis Author(s) Zablotskyy, Vitaliy A. (FZU-D) RID
Lunov, O. (DE)
Dejneka, Alexandr (FZU-D) RID, ORCID
Jastrabík, Lubomír (FZU-D) RID, ORCID
Polyakova, T. (UA)
Syrovets, T. (DE)
Simmet, T. (DE)Source Title Applied Physics Letters. - : AIP Publishing - ISSN 0003-6951
Roč. 99, č. 18 (2011), 183701/1-183701/3Number of pages 3 s. Language eng - English Country US - United States Keywords magnetically controled endocytosis ; cell membranes ; iron oxide nanoparticles Subject RIV BM - Solid Matter Physics ; Magnetism R&D Projects KAN301370701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M06002 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z10100522 - FZU-D (2005-2011) UT WOS 000296659400100 DOI 10.1063/1.3656020 Annotation Being essential for many pharmacodynamic and pharmacokinetic processes and playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms in many aspects still remain a mystery and therefore can hardly be controlled. Here, we report on experimental and modeling studies of the magnetically assisted endocytosis of functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) and characterize the time and force scales of the cellular uptake machinery. The results indicate how the cellular uptake rate could be controlled by applied magnetic field, membrane elasticity, and nanoparticle magnetic moment. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2012
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