Number of the records: 1

Functionalization of osmium arene anticancer complexes with (poly)arginine: Effect on cellular uptake, internalization, and cytotoxicity

SYSNO ASEP	0367048
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Functionalization of osmium arene anticancer complexes with (poly)arginine: Effect on cellular uptake, internalization, and cytotoxicity
Author(s)	van Rijt, S.H. (GB) Kostrhunová, Hana (BFU-R)_{RID, ORCID} Brabec, Viktor (BFU-R)_{RID, ORCID} Sadler, P.J. (GB)
Number of authors	4
Source Title	Bioconjugate Chemistry. - : American Chemical Society - ISSN 1043-1802 Roč. 22, č. 2 (2011), s. 218-226
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	osmium ; arginine ; cellular accumulation
Subject RIV	BO - Biophysics
R&D Projects	GAP301/10/0598 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000287297000015
DOI	10.1021/bc100369p
Annotation	Os complexes conjugated to Arg5 and Arg8 increase Os uptake into A2780 human ovarian cancer cells by 2x and 10x, respectively. A 15-fold increase in binding of Os to DNA was observed for Arg8. The complexes exhibited an ability to precipitate DNA.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2012

Number of the records: 1