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Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases
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SYSNO ASEP 0366631 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases Author(s) Jančová, P. (CZ)
Šiller, M. (CZ)
Anzenbacherová, E. (CZ)
Křen, Vladimír (MBU-M) RID, ORCID
Anzenbacher, P. (CZ)
Šimánek, V. (CZ)Source Title Xenobiotica. - : Taylor & Francis - ISSN 0049-8254
Roč. 41, č. 9 (2011), s. 743-751Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords Silybin ; conjugation ; metabolism Subject RIV CE - Biochemistry CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000293465300001 DOI 10.3109/00498254.2011.573017 Annotation The flavonolignan silybin, the main component of silymarin, extract from the seeds of Silybum marianum, is used mostly as a hepatoprotectant. Silybin is almost 1:1 mixture of two diastereomers A and B. The individual UDP-glucuronosyltransferases (UGTs) contributing to the metabolism of silybin diastereomers have not been identified yet. In this study, the contribution of UGTs to silybin metabolism was examined Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
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