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Computational Modelling of Catalytic Properties and Modified Substrates of Fungal B-N-Acetylhexosaminidases

SYSNO ASEP	0366489
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Computational Modelling of Catalytic Properties and Modified Substrates of Fungal B-N-Acetylhexosaminidases
Author(s)	Kulik, Natallia (UEK-B)_RID Slámová, Kristýna (MBU-M)_{RID, ORCID}
Source Title	Mini - Reviews in Organic Chemistry - ISSN 1570-193X Roč. 8, č. 3 (2011), s. 270-280
Number of pages	11 s.
Language	eng - English
Country	AE - United Arab Emirates
Keywords	beta-N-Acetylhexosaminidase ; computer modelling ; modified substrate
Subject RIV	CE - Biochemistry
R&D Projects	GAP207/11/0629 GA ČR - Czech Science Foundation (CSF)
	GD305/09/H008 GA ČR - Czech Science Foundation (CSF)
	LC06010 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
	AV0Z60870520 - UEK-B (2005-2011)
UT WOS	000294408500008
DOI	10.2174/157019311796197418
Annotation	Besides their implication in human physiology and disease, b-N-acetylhexosaminidases (EC 3.2.1.52, CAZy GH 20) have recently gained a lot of attention thanks to their great potential in the enzymatic synthesis of carbohydrates and glycomimetics. Extracellular b -N-acetylhexosaminidases from filamentous fungi proved to be a powerful synthetic tool for the preparation of both natural and modified glycosides under mild conditions with good yields. A homology model of b-N-acetylhexosaminidase from the filamentous fungus Aspergillus oryzae has recently been reported, and its quality was corroborated by vibrational spectroscopy and biochemical studies
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2012

Number of the records: 1