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Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

SYSNO ASEP	0366420
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light
Author(s)	Nováková, Marta (FGU-C) Polidarová, Lenka (FGU-C)_{RID, ORCID} Sládek, Martin (FGU-C)_{RID, ORCID, SAI} Sumová, Alena (FGU-C)_{RID, ORCID}
Source Title	Neuroscience. - : Elsevier - ISSN 0306-4522 Roč. 197, - (2011), s. 65-71
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	circadian system ; suprachiasmatic nucleus ; restricted feeding ; constant light
Subject RIV	FH - Neurology
R&D Projects	GA305/09/0321 GA ČR - Czech Science Foundation (CSF)
	GAP303/11/0668 GA ČR - Czech Science Foundation (CSF)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000297140700007
DOI	10.1016/j.neuroscience.2011.09.028
Annotation	The aim of the study was to elucidate whether feeding regime may affect the molecular mechanisms generating rhythmicity in the suprachiasmatic nucleus (SCN) under conditions in which the rhythmicity is disturbed, as occurs under constant light. Due to exposure to constant light, the rats fed ad libitum became arrhythmic, while those exposed to restricted feeding were active mostly during the time of food availability. Restricted feeding induced significant circadian rhythms in Rev-erbα and Bmal1 gene expression in the SCN. These finding demonstrate that, under specific conditions, when the rhythmicity of the SCN is disturbed and other temporal entraining cues are lacking, the SCN molecular clockwork may likely sense temporal signals from changes in metabolic state delivered by normocaloric food
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1