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Synthesis and Biological Applications of Glycoconjugates
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SYSNO ASEP 0366245 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Glycosidases in Synthesis of Glycomimetics and Unnatural Carbohydrates Author(s) Křen, Vladimír (MBU-M) RID, ORCID Source Title Synthesis and Biological Applications of Glycoconjugates. - Velká Británie : Bentham Science Publishers Ltd, 2011 / Renaudet Olivier ; Spinelli Nicolas - ISBN 978-1-60805-277-6 Pages s. 226-239 Number of pages 14 s. Number of copy 1000 Number of pages 275 Language eng - English Country GB - United Kingdom Keywords glycosidase ; glycosynthase ; thioglycoligase Subject RIV CC - Organic Chemistry R&D Projects LC06010 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) DOI 10.2174/978160805277611101010226 Annotation In recent years, carbohydrate-processing enzymes have become the enzymes of choice in many applications thanks to their stereoselectivity and efficiency. This chapter presents recent development in glycosidase-catalyzed synthesis of unnatural semisynthetic carbohydrate structures via two complementary approaches: the use of wild-type enzymes with engineered substrates and mutant glycosidases. Genetic engineering has recently produced glucuronyl synthases, an inverting xylosynthase and the first mutant endo-β-N-acetylglucosaminidase Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
Number of the records: 1