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Charged Hexosaminides as New Substrates for β-N-Acetylhexosaminidase-Catalyzed Synthesis of Immunomodulatory Disaccharides

SYSNO ASEP	0366186
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Charged Hexosaminides as New Substrates for β-N-Acetylhexosaminidase-Catalyzed Synthesis of Immunomodulatory Disaccharides
Author(s)	Bojarová, Pavla (MBU-M)_ORCID Slámová, Kristýna (MBU-M)_{RID, ORCID} Křenek, Karel (MBU-M) Gažák, Radek (MBU-M)_{RID, ORCID} Kulik, Natallia (UEK-B)_RID Ettrich, Rüdiger (UEK-B)_{RID, ORCID, SAI} Pelantová, Helena (MBU-M)_{ORCID, RID} Kuzma, Marek (MBU-M)_{ORCID, RID} Riva, S. (IT) Adámek, David (MBU-M) Bezouška, Karel (MBU-M) Křen, Vladimír (MBU-M)_{RID, ORCID}
Source Title	Advanced Synthesis & Catalysis. - : Wiley - ISSN 1615-4150 Roč. 353, č. 13 (2011), s. 2409-2420
Number of pages	12 s.
Language	eng - English
Country	DE - Germany
Keywords	beta-N-acetylhexosaminidase ; biotransformations ; charged glycosides
Subject RIV	CC - Organic Chemistry
R&D Projects	GP203/09/P024 GA ČR - Czech Science Foundation (CSF)
	GD305/09/H008 GA ČR - Czech Science Foundation (CSF)
	GA303/09/0477 GA ČR - Czech Science Foundation (CSF)
	GAP207/11/0629 GA ČR - Czech Science Foundation (CSF)
	LC06010 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
	AV0Z60870520 - UEK-B (2005-2011)
UT WOS	000295230900020
DOI	10.1002/adsc.201100371
Annotation	This work is a structure-activity relationship study that investigates the influence of the nature and amount of negative charge in carbohydrate substrates on the affinity of β-N-acetylhexos-aminidases, and on the stimulation of natural killer cells. It describes synthetic procedures yielding novel glycosides that are useful in immunoactivation. Specifically, we present a thorough study on the ability of six C-6 modified β-N-acetylhexosaminides (aldehyde, uronate, 6-O-sulfate, 6-O-phosphate) to serve as substrates for cleavage and glycosylation by a library of β-N-acetylhexosaminidases from various sources
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2012

Number of the records: 1