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Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice

SYSNO ASEP	0366099
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice
Author(s)	Pirnik, Z. (SK) Bundziková, J. (SK) Holubová, Martina (UOCHB-X)_{RID, ORCID} Pýchová, Miroslava (UOCHB-X) Fehrentz, J. A. (FR) Martinez, J. (FR) Železná, Blanka (UOCHB-X)_{RID, ORCID} Maletínská, Lenka (UOCHB-X)_{RID, ORCID} Kiss, A. (SK)
Number of authors	9
Source Title	Neurochemistry International. - : Elsevier - ISSN 0197-0186 Roč. 59, č. 6 (2011), s. 889-895
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	ghrelin agonists ; Fos immunohistochemistry ; male C57BL/6 mice
Subject RIV	CC - Organic Chemistry
R&D Projects	GA303/09/0744 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000297400700017
DOI	10.1016/j.neuint.2011.08.001
Annotation	Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable analogues, agonists: Dpr3ghr ([Dpr(N-octanoyl)3] ghrelin) (Dpr – diaminopropionic acid), YA GHRP-6 (Tyr-Ala-His-DTrp-Ala-Trp-DPhe-Lys-NH2), and JMV1843 (H-Aib-DTrp-D-gTrp-CHO) on the Fos expression in food intake-responsive brain areas such as the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei, the nucleus of the solitary tract (NTS), and area postrena (AP) in male C57BL/6 mice. Immunohistochemical analysis showed that acute SC administration of each of these substances, in dose (5 mg/kg b.w.), which induce strong food intake increase, elevated Fos protein expression in all brain areas studied.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1