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Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury

SYSNO ASEP	0366090
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury
Author(s)	Arboleda Toro, David (UEM-P) Forostyak, Serhiy (UEM-P)_{RID, ORCID} Jendelová, Pavla (UEM-P)_{RID, ORCID} Mareková, Dana (UEM-P) Amemori, Takashi (UEM-P)_RID Pivoňková, Helena (UEM-P) Mašínová, Katarína (UEM-P) Syková, Eva (UEM-P)_RID
Source Title	Cellular and Molecular Neurobiology. - : Springer - ISSN 0272-4340 Roč. 31, č. 7 (2011), s. 1113-1122
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	Adipose tissue ; Differentiation ; Mesenchymal stromal cells
Subject RIV	FH - Neurology
R&D Projects	GA305/09/0717 GA ČR - Czech Science Foundation (CSF)
	IAA500390902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50390512 - UEM-P (2005-2011)
	AV0Z50390703 - UEM-P (2007-2013)
UT WOS	000295169500017
DOI	10.1007/s10571-011-9712-3
Annotation	The purpose of the study was to compare predifferentiated ASCs (pASCs) with naïve ASCs in vitro and after transplantation into rats with a balloon-induced spinal cord compression lesion. ASC spheres were induced prior to transplantation, then pASCs or ASCs were injected intraspinally. Behavioral, histological and electrophysiological methods were used to assess the cells' fate and the rats' functional outcome.The predifferentiation of ASCs facilitated the protection of denuded axons; however, functional improvement was comparable in both groups, indicating that repair was induced mainly through paracrine mechanisms.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2012

Number of the records: 1