Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface

Number of the records: 1

1.

SYSNO ASEP	0366020
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface
Author(s)	Antolíková, Emília (UOCHB-X) Žáková, Lenka (UOCHB-X)_{RID, ORCID} Turkenburg, J. P. (GB) Watson, C. J. (GB) Hančlová, Ivona (UOCHB-X) Šanda, Miloslav (UOCHB-X) Cooper, A. (GB) Kraus, Tomáš (UOCHB-X)_{RID, ORCID} Brzozowski, A. M. (GB) Jiráček, Jiří (UOCHB-X)_{RID, ORCID}
Number of authors	10
Source Title	Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258 Roč. 286, č. 42 (2011), s. 36968-36977
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	insulin ; dimer ; analog
Subject RIV	CC - Organic Chemistry
R&D Projects	LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000296538300075
DOI	10.1074/jbc.M111.265249
Annotation	Using selective N-methylation, we systematically investigated the role of peptide bond amide hydrogens at positions B24, B25 and B26 in insulin for the dimerization ability and for the affinity of the hormone towards insulin receptor.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2012

Number of the records: 1