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Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes
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SYSNO ASEP 0365887 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes Author(s) Cang, X. (US)
Šponer, Jiří (BFU-R) RID, ORCID
Cheatham III, T.E. (US)Number of authors 3 Source Title Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048
Roč. 39, č. 10 (2011), s. 4499-4512Number of pages 14 s. Language eng - English Country US - United States Keywords quantum chemistry ; DNA ; quadruplex Subject RIV BO - Biophysics R&D Projects LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA400040802 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA203/09/1476 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000291063500048 DOI 10.1093/nar/gkr031 Annotation Guanine-rich DNA sequences tend to form four-stranded G-quadruplex structures. Characteristic glycosidic conformational patterns along the G-strands, such as the 50-syn-anti-syn-anti pattern observed with the Oxytricha nova telomeric G-quadruplexes, have been well documented. However, an explanation for these featured glycosidic patterns has not emerged. This work presents MD simulation and free energetic analyses for simplified two-quartet [d(GG)]4 models and suggests that the four base pair step patterns show quite different relative stabilities: syn-anti>anti-anti>anti-syn->syn-syn. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2012
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