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Intra- and Interindividual Variability in Lymphocyte Chromosomal Aberrations: Implications for Cancer Risk Assessment
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SYSNO ASEP 0365858 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Intra- and Interindividual Variability in Lymphocyte Chromosomal Aberrations: Implications for Cancer Risk Assessment Author(s) Peters, S. (NL)
Portengen, L. (NL)
Bonassi, S. (IT)
Šrám, Radim (UEM-P) RID
Vermeulen, R. (NL)Source Title American Journal of Epidemiology - ISSN 0002-9262
Roč. 174, č. 4 (2011), s. 490-493Number of pages 4 s. Language eng - English Country US - United States Keywords chromosomal aberrations frequency ; cancer risk assessment Subject RIV DN - Health Impact of the Environment Quality CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000293595300013 EID SCOPUS 80051512974 DOI 10.1093/aje/kwr114 Annotation Chromosomal aberration (CA) frequency in peripheral lymphocytes of healthy individuals has been found to be predictive of future cancer risk. Intra- and interindividual variability in CA frequency was determined. From a pooled database comprising 11 national cohorts (1965-2002) the authors included 9,433 blood samples from 3,550 subjects with at least one repeated CA measurement. The generalized concordance correlation coeff. of 0.19 was low, indicating high intraindividual variability compared with interindividual variability, resulting in a high likelihood of missclassification. The authors stated that the relation between CA frequency and future cancer risk has probably been underestimated in previous studies. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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