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High-field gradient permanent micromagnets for targeted drug delivery with magnetic nanoparticles
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SYSNO ASEP 0365807 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title High-field gradient permanent micromagnets for targeted drug delivery with magnetic nanoparticles Author(s) Zablotskyy, Vitaliy A. (FZU-D) RID
Pastor, J. M. (ES)
Larumbe, S. (ES)
Pérez-Landazábal, J.I. (ES)
Recarte, V. (ES)
Gómez-Polo, C. (ES)Source Title 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. - Melville : American institute of physics, 2010 / Häfeli U. ; Schütt W. ; Zborowski M. - ISSN 0094-243X - ISBN 978-0-7354-0866-1 Pages s. 152-157 Number of pages 6 s. Action International Conference on the Scientific and Clinical Applications of Magnetic Carriers /8./ Event date 25.05.2010-29.05.2010 VEvent location Rostock Country DE - Germany Event type WRD Language eng - English Country US - United States Keywords micromagnets ; drug delivery ; magnetic nanoparticles Subject RIV BM - Solid Matter Physics ; Magnetism CEZ AV0Z10100522 - FZU-D (2005-2011) UT WOS 000287170600022 Annotation We analytically investigate several micromagnetic systems aimed at the optimization of drug and gene delivery processes and show their applicability to the controlled positioning of magnetic nanoparticles. The systems considered are: i) a square array of cylindrical microneedles, ii) a planar stepped array of magnets, and iii) a Halbach array of micromagnets. We calculate spatial distributions of force components acting on a magnetic nanoparticle and the field gradients produced by these magnetic configurations. These calculations show that array geometries tend to enhance the field gradients and forces that can be obtained from a given material. The benefits of the proposed micromagnetic systems—tunability, scalability, and ability of creation of magnetic flux distributions with high-gradient areas allowing precise focusing of magnetic nanoparticles (MNPs)—are also discussed. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2012
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