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Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
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SYSNO ASEP 0365728 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function Author(s) McDermott-Roe, Ch. (GB)
Ye, J. (ES)
Ahmed, R. (GB)
Sun, X. M. (GB)
Serafín, A. (ES)
Ware, J. (GB)
Bottolo, L. (GB)
Muckett, P. (GB)
Caňas, X. (ES)
Zhang, J. (ES)
Rowe, G. C. (US)
Buchan, R. (GB)
Lu, H. (GB)
Braithwaite, A. (GB)
Mancini, M. (IT)
Hauton, D. (GB)
Martí, R. (ES)
García-Arumí, E. (ES)
Hubner, N. (DE)
Jacob, H. (US)
Serikawa, T. (JP)
Zídek, Václav (FGU-C) RID
Papoušek, František (FGU-C)
Kolář, František (FGU-C) RID, ORCID, SAI
Cardona, M. (ES)
Ruiz-Meana, M. (ES)
García-Dorado, D. (ES)
Comella, J. X. (ES)
Felkin, L. E. (GB)
Barton, P. J. R. (GB)
Arany, Z. (US)
Pravenec, Michal (FGU-C) RID, ORCID
Petretto, E. (GB)
Sanchis, D. (ES)
Cook, S.A. (GB)Source Title Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 478, č. 7367 (2011), s. 114-118Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords left ventricular hypertrophy ; endonuclease G ; mitochondrial dysfunction Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA301/08/0166 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000295575400045 DOI 10.1038/nature10490 Annotation Left ventricular mass (LVM) is a highly heritable trait and an independent risk factor for all-cause mortality. We identified mutation in endonuclease G (Endog) that is associated with increased LVM and impaired cardiac function. Our study has further established the link between mitochondrial dysfunction, reactive oxygen species and heart disease and has uncovered a role for Endog in maladaptive cardiac hypertrophy Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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