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Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1alfa fusion protein; the effect of cholesterol depletion

SYSNO ASEP	0365285
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1alfa fusion protein; the effect of cholesterol depletion
Author(s)	Brejchová, Jana (FGU-C)_{RID, ORCID} Sýkora, Jan (UFCH-W)_RID Dlouhá, Kateřina (FGU-C) Roubalová, Lenka (FGU-C)_{RID, ORCID, SAI} Ostašov, Pavel (FGU-C) Vošahlíková, Miroslava (FGU-C)_{RID, ORCID, SAI} Hof, Martin (UFCH-W)_{RID, ORCID} Svoboda, Petr (FGU-C)_{RID, ORCID}
Source Title	Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736 Roč. 1808, č. 12 (2011), s. 2819-2829
Number of pages	11 s.
Language	eng - English
Country	NL - Netherlands
Keywords	plasma membrane ; cholesterol depletion ; fluorescence spectroscopy ; hydrophobic membrane interior ; delta-opioid receptor (DOR), ; G protein
Subject RIV	BO - Biophysics
R&D Projects	LC06063 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GD305/08/H037 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
	AV0Z40400503 - UFCH-W (2005-2011)
UT WOS	000296938600006
DOI	10.1016/j.bbamem.2011.08.010
Annotation	Effect of cholesterol on the organization of plasma membranes and G-protein activation. Cholesterol depletion increases membrane fluidity and mobility of plasma membranes. Cholesterol depletion does not alter the agonist binding site of delta-opioid receptor (DOR), but decreases the ability of DOR agonist to activate G proteins
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1