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The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure
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SYSNO ASEP 0365117 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure Author(s) Rohoušová, I. (CZ)
Hostomská, J. (CZ)
Vlková, M. (CZ)
Kobets, Tetyana (UMG-J) RID
Lipoldová, Marie (UMG-J) RID
Volf, P. (CZ)Source Title International Journal for Parasitology. - : Elsevier - ISSN 0020-7519
Roč. 41, č. 5 (2011), s. 481-485Number of pages 5 s. Language eng - English Country AU - Australia Keywords Phlebotomus duboscqi ; Leishmania major ; anti-saliva IgG Subject RIV EB - Genetics ; Molecular Biology R&D Projects LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000289402300002 DOI 10.1016/j.ijpara.2011.01.003 Annotation Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2012
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