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How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels
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SYSNO ASEP 0365082 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels Author(s) Kochová, P. (CZ)
Cimrman, R. (CZ)
Janáček, Jiří (FGU-C) RID, ORCID
Witter, K. (AT)
Tonar, Z. (CZ)Source Title Journal of Theoretical Biology. - : Elsevier - ISSN 0022-5193
Roč. 286, - (2011), s. 67-78Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords rose of directions ; preferential directions ; chi-square test ; length density ; python Subject RIV EA - Cell Biology CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000294975800008 DOI 10.1016/j.jtbi.2011.07.004 Annotation In our study, we present a novel p(chi2) (chi-square) method for evaluating the anisotropy of line systems that involves comparing the observed length densities of lines with the discrete uniform distribution of an isotropic line system with the chi2-test. Using this method in our open source software, we determined the rose of directions, preferential directions and level of anisotropy of linear systems representing the microscopic blood vessels in samples of various regions from human brains (cortex, subcortical gray matter and white matter). The novel method was compared with two other methods used for anisotropy quantification (ellipsoidal and fractional anisotropy). All three methods detected different levels of anisotropy of blood microvessels in human brain. The microvascular bed in the cortex was closer to an isotropic network, while the microvessels supplying the white matter appeared to be an anisotropic and direction-sensitive system Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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