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Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments
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SYSNO ASEP 0365079 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments Author(s) Wilhelm, J. (CZ)
Ivica, J. (CZ)
Kagan, Dmytro (FGU-C)
Svoboda, Petr (FGU-C) RID, ORCIDSource Title Molecular and Cellular Biochemistry. - : Springer - ISSN 0300-8177
Roč. 347, 1-2 (2011), s. 157-162Number of pages 6 s. Language eng - English Country US - United States Keywords brain ; early development ; lipofuscin-like pigments ; fluorescence ; rat Subject RIV CE - Biochemistry R&D Projects LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA500110606 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000285421500017 DOI 10.1007/s11010-010-0623-2 Annotation The increased generation of free radicals results in the formation of fluorescent end-products of lipid peroxidation, lipofuscin-like pigments (LFPs). The authors observed that LFPs are generated in rat brain after a normal birth during 5 postnatal days. Maximum LFP concentration is achieved on the postnatal day 2. Starting from postnatal day 10, LFP concentration returns to prenatal values. A new rise in LFP concentration is observed at 3 months of age. This is associated with the beginning of the aging process. The authors suggest that LFPs are formed after respiratory burst of microglia phagocytosing apoptotic cells Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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