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Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
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SYSNO ASEP 0365067 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor Author(s) Petrenko, N. (FI)
Khafizov, K. (DE)
Tvrdoňová, Vendula (FGU-C)
Skorinkin, A. (RU)
Giniatullin, R. (FI)Source Title Biochemistry. - : American Chemical Society - ISSN 0006-2960
Roč. 50, č. 39 (2011), s. 8427-8436Number of pages 10 s. Language eng - English Country US - United States Keywords P2X3 ; purinergic ; ATP ; ATP-binding pocket ; receptor Subject RIV ED - Physiology CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000295187200018 DOI 10.1021/bi200812u Annotation In this work, by exploring in silico the functional role for the left flipper located in the ectodomain region, we identified within this loop a candidate residue S275, which could contribute to the closure of the agonist-binding pocket. Testing of the S275 mutants using the patch-clamp technice revealed a crucial role for S275 in agonist binding and receptor desensitization Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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