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The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole

SYSNO ASEP	0365057
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole
Author(s)	Mesárošová, M. (SK) Valovičová, Z. (SK) Srančíková, A. (SK) Krajčovičová, Z. (SK) Milcová, Alena (UEM-P) Sokolová, Romana (UFCH-W)_{RID, ORCID, SAI} Schmuczerová, Jana (UEM-P)_RID Topinka, Jan (UEM-P)_{RID, ORCID} Gábelová, A. (SK)
Source Title	Toxicology and Applied Pharmacology. - : Elsevier - ISSN 0041-008X Roč. 255, č. 3 (2011), s. 307-315
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	cytochrome P4503A4 ; 7H-dibenzo[c,g]carbazole ; Hprt gene mutations
Subject RIV	DN - Health Impact of the Environment Quality
R&D Projects	2B08005 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50390512 - UEM-P (2005-2011)
	AV0Z40400503 - UFCH-W (2005-2011)
	AV0Z50040507 - BFU-R (2005-2011)
UT WOS	000295021100008
EID SCOPUS	80052384567
DOI	10.1016/j.taap.2011.06.027
Annotation	The environmental pollutant 7H-dibenzo[c,g]carbazole (DBC) and its derivative, 5,9-dimethylDBC (DiMeDBC), produced significant and dose-dependent levels of micronuclei followed by a substantial increase in the frequency of apoptotic cells in the V79MZh3A4 cell line stably expressing the human cytochrome P450 (hCYP) 3A4. In contrast, neither micronuclei nor apoptosis were found in cells exposed to the sarcomagenic carcinogen, N-methylDBC (N-MeDBC). Based on our results, we suggest that hCYP3A4 is involved in the metabolism of DBC and its tissue-specific derivatives. While hCYP3A4 probably plays an important role in biotransformation of the liver carcinogens, DBC and DiMeDBC, it might only have a marginal function in N-MeDBC metabolism.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2012

Number of the records: 1