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How a Neutral Evolutionary Ratchet Can Build Cellular Complexity
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SYSNO ASEP 0364838 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title How a Neutral Evolutionary Ratchet Can Build Cellular Complexity Author(s) Lukeš, Julius (BC-A) RID, ORCID
Archibald, J.M. (CA)
Keeling, P.J. (CA)
Doolittle, W.F. (CA)
Gray, M.W. (CA)Source Title Iubmb Life. - : Wiley - ISSN 1521-6543
Roč. 63, č. 7 (2011), 528-537Number of pages 10 s. Language eng - English Country US - United States Keywords neutral evolution ; adaptation ; selection Subject RIV EB - Genetics ; Molecular Biology R&D Projects LC07032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000292944000011 DOI 10.1002/iub.489 Annotation Here, we describe how complex machines might evolve in the absence of positive selection through a process of "presuppression," first termed constructive neutral evolution (CNE) more than a decade ago. If an autonomously functioning cellular component acquires mutations that make it dependent for function on another, preexisting component or process, and if there are multiple ways in which such dependence may arise, then dependence inevitably will arise and reversal to independence is unlikely. Thus, CNE is a unidirectional evolutionary ratchet leading to complexity, if complexity is equated with the number of components or steps necessary to carry out a cellular process. CNE can explain "functions" that seem to make little sense in terms of cellular economy, like RNA editing or splicing, but it may also contribute to the complexity of machines with clear benefit to the cell, like the ribosome, and to organismal complexity overall. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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