Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors

Alfonzo, J. D.; Lukeš, Julius

doi:https://dx.doi.org/10.1016/j.pt.2011.02.003

Number of the records: 1

Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors

1.

SYSNO ASEP	0364802
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors
Author(s)	Alfonzo, J. D. (US) Lukeš, Julius (BC-A)_{RID, ORCID}
Source Title	Trends in Parasitology. - : Elsevier - ISSN 1471-4922 Roč. 27, č. 6 (2011), 234-237
Number of pages	4 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	IRON-SULFUR CLUSTERS ; TRYPANOSOMA-BRUCEI ; MITOCHONDRIAL ; PROTEIN ; FRATAXIN ; BIOSYNTHESIS ; SYNTHETASES ; BIOGENESIS ; THIOLATION ; ANTICODON
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LC07032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA204/09/1667 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000292238800003
DOI	10.1016/j.pt.2011.02.003
Annotation	Trypanosome brucei undergoes two clearly distinct develomental stages: in the insect vector (procyclic stage) the cells generate the bulk of their energy through respiration, whereas in the bloodstream of the mammalian host (bloodstream stage) they grow mostly glycolytically. Several mitochondrial respiratory proteins require iron-sulfur clusters for activity, and their activation coincides with developmental changes. Likewise some tRNA modification enzymes either require iron-sulfur clusters or use components of the iron-sulfur cluster assembly pathway for activity. These enzymes affect the anticodon loop of various tRNAs and can impact protein synthesis. Herein, the possibility of these pathways being integrated and exploited by T. brucei to carefully coordinate energy demands to translational rates in response to enviromental changes is examined.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2012

Number of the records: 1