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Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus
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SYSNO ASEP 0364792 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus Author(s) Zemková, Hana (FGU-C) RID, ORCID
Stojilkovič, S.S. (US)
Klein, D. C. (US)Source Title Endocrinology - ISSN 0013-7227
Roč. 152, č. 10 (2011), s. 3842-3851Number of pages 10 s. Language eng - English Country US - United States Keywords Ca2plus-activated Kplus channels ; voltage-gated Ca2plus channels ; electrical activity ; pinealocyte Subject RIV ED - Physiology R&D Projects GA305/07/0681 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000295081200029 DOI 10.1210/en.2011-1180 Annotation The pineal gland is a neuroendocrine transducer, which generates a nocturnal increase in melatonin production, reflecting stimulation by norepinephrine (NE). NE was found to act through alpha1B-adrenoreceptors in a concentration-dependent manner to produce a biphasic change in membrane potential: initial transient hyperpolarization is followed by stable depolarization. These observations indicate that both continuous elevation of intracellular Ca2plus and sustained depolarization are associated with and are likely to be required for activation of the pinealocyte Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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